abstract：:The transcription factor Nuclear Factor Kappa B (NF-κB) has been shown to be cardioprotective after permanent coronary occlusion (PO) and late ischemic preconditioning (IPC), and yet it is cell injurious after ischemia/reperfusion (I/R) in the heart. There is limited information regarding NF-κB-dependent cardioprotect...

journal_title：Journal of molecular and cellular cardiology

authors： Wilhide ME,Tranter M,Ren X,Chen J,Sartor MA,Medvedovic M,Jones WK

更新日期：2011-07-01 00:00:00

abstract：:Cardiac disease is frequently associated with abnormalities in electrical function that can severely impair cardiac performance with potentially fatal consequences. The available therapeutic options have some efficacy but are far from perfect. The curative potential of gene therapy makes it an attractive approach for ...

journal_title：Journal of molecular and cellular cardiology

authors： Greener I,Donahue JK

更新日期：2011-05-01 00:00:00

abstract：:Local signaling domains and numerous interacting molecular pathways and substrates contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS). We aimed to elucidate the quantitative contribution of substrates and their local signaling environments during βARS to the canine epicardial vent...

journal_title：Journal of molecular and cellular cardiology

authors： Heijman J,Volders PG,Westra RL,Rudy Y

更新日期：2011-05-01 00:00:00

abstract：:Current pharmacologic therapy for ischemic heart disease suffers multiple limitations such as compliance issues and side effects of medications. Revascularization procedures often end with need for repeat procedures. Patients remain symptomatic despite maximal medical therapy. Gene therapy offers an attractive alterna...

journal_title：Journal of molecular and cellular cardiology

authors： Lavu M,Gundewar S,Lefer DJ

更新日期：2011-05-01 00:00:00

abstract：:The atrioventricular conduction axis, located in the septal component of the atrioventricular junctions, is arguably the most complex structure in the heart. It fulfils a multitude of functions, including the introduction of a delay between atrial and ventricular systole and backup pacemaking. Like any other multifunc...

journal_title：Journal of molecular and cellular cardiology

authors： Greener ID,Monfredi O,Inada S,Chandler NJ,Tellez JO,Atkinson A,Taube MA,Billeter R,Anderson RH,Efimov IR,Molenaar P,Sigg DC,Sharma V,Boyett MR,Dobrzynski H

更新日期：2011-04-01 00:00:00

abstract：:The diabetic heart becomes metabolically remodelled as a consequence of exposure to abnormal circulating substrates and hormones. Fatty acid uptake and metabolism are increased in the type 2 diabetic heart, resulting in accumulation of intracellular lipid intermediates and an increased contribution of fatty acids towa...

journal_title：Journal of molecular and cellular cardiology

authors： Heather LC,Clarke K

更新日期：2011-04-01 00:00:00

abstract：:Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filaments of the sarcomere. Understanding the structural and functional role of cMyBP-C in the heart is clinically relevant since cMyBP-C gene mutations are a widely recognized cause of hypertrophic cardiomyopathy (HCM), which affects 0.2% of the g...

journal_title：Journal of molecular and cellular cardiology

authors： Schlossarek S,Mearini G,Carrier L

更新日期：2011-04-01 00:00:00

abstract：:Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured tissue by differentiating into specialized cardiac cell lineages and/or manipulating the cell and molecular mechanisms governing repair. Despite early reports describing ...

journal_title：Journal of molecular and cellular cardiology

authors： Mirotsou M,Jayawardena TM,Schmeckpeper J,Gnecchi M,Dzau VJ

更新日期：2011-02-01 00:00:00

abstract：:In cardiac regenerative therapy, transplantation of stem cells to form new myocardium is limited by their inability to integrate into host myocardium and conduct cardiac electrical activity. It is now hypothesized that refining cell sorting could upgrade the therapeutic result. Here we characterized a subpopulation of...

journal_title：Journal of molecular and cellular cardiology

authors： Poulet C,Wettwer E,Christ T,Ravens U

更新日期：2011-02-01 00:00:00

abstract：:Oxidative stress plays a crucial role in disruption of neovascularization by alterations in thioredoxin 1 (Trx1) expression and its interaction with other proteins after myocardial infarction (MI). We previously showed that Trx1 has angiogenic properties, but the possible therapeutic significance of overexpressing Trx...

journal_title：Journal of molecular and cellular cardiology

authors： Adluri RS,Thirunavukkarasu M,Zhan L,Akita Y,Samuel SM,Otani H,Ho YS,Maulik G,Maulik N

更新日期：2011-01-01 00:00:00

abstract：:Forces associated with blood flow are crucial not only for blood vessel development but also for regulation of vascular pathology. Although there have been many studies characterizing the responses to mechanical stimuli, molecular mechanisms linking biological responses to mechanical forces remain unclear. Hic-5 (hydr...

journal_title：Journal of molecular and cellular cardiology

authors： Kim-Kaneyama JR,Takeda N,Sasai A,Miyazaki A,Sata M,Hirabayashi T,Shibanuma M,Yamada G,Nose K

更新日期：2011-01-01 00:00:00

abstract：:Diastolic dysfunction in the aging heart is a grave condition that challenges the life and lifestyle of a growing segment of our population. This report seeks to examine the role and interrelationship of inflammatory dysregulation in interstitial myocardial fibrosis and progressive diastolic dysfunction in aging mice....

journal_title：Journal of molecular and cellular cardiology

authors： Cieslik KA,Taffet GE,Carlson S,Hermosillo J,Trial J,Entman ML

更新日期：2011-01-01 00:00:00

abstract：:α-Keto acids (α-KAs) are not just metabolic intermediates but are also powerful modulators of different cellular pathways. Here, we tested the hypothesis that α-KA concentrations are regulated by complex II (succinate dehydrogenase=SDH), which represents an intersection between the mitochondrial respiratory chain for ...

journal_title：Journal of molecular and cellular cardiology

authors： Mühling J,Tiefenbach M,López-Barneo J,Piruat JI,García-Flores P,Pfeil U,Gries B,Mühlfeld C,Weigand MA,Kummer W,Weissmann N,Paddenberg R

更新日期：2010-12-01 00:00:00

abstract：:We investigated the role of neuropeptide Y (NPY), abundant in the myocardial sympathetic nervous system and endothelial cells, in angiogenesis during chronic myocardial ischemia. Adult male Yorkshire swine underwent ameroid constrictor placement on the proximal left circumflex coronary artery. After 3 weeks, an osmoti...

journal_title：Journal of molecular and cellular cardiology

authors： Robich MP,Matyal R,Chu LM,Feng J,Xu SH,Laham RJ,Hess PE,Bianchi C,Sellke FW

更新日期：2010-12-01 00:00:00

abstract：:Patients with diabetes mellitus can develop cardiac dysfunction in the absence of underlying coronary artery disease or hypertension; a condition defined as diabetic cardiomyopathy. Mice lacking the intracellular protein kinase Akt2 develop a syndrome that is similar to diabetes mellitus type 2. Expression profiling o...

journal_title：Journal of molecular and cellular cardiology

authors： Etzion S,Etzion Y,DeBosch B,Crawford PA,Muslin AJ

更新日期：2010-12-01 00:00:00

abstract：:The Ca(2+) dependent interaction between troponin I (cTnI) and troponin C (cTnC) triggers contraction in heart muscle. Heart failure is characterized by a decrease in cardiac output, and compounds that increase the sensitivity of cardiac muscle to Ca(2+) have therapeutic potential. The Ca(2+)-sensitizer, levosimendan,...

journal_title：Journal of molecular and cellular cardiology

authors： Robertson IM,Sun YB,Li MX,Sykes BD

更新日期：2010-12-01 00:00:00

abstract：:Celecoxib is a COX-2 inhibitor that has been related to an increased cardiovascular risk and that exerts several actions on different targets. The aim of this study was to analyze the effects of this drug on human cardiac voltage-gated potassium channels (Kv) involved on cardiac repolarization Kv1.5 (I(Kur)), Kv4.3+KC...

journal_title：Journal of molecular and cellular cardiology

authors： Macías A,Moreno C,Moral-Sanz J,Cogolludo A,David M,Alemanni M,Pérez-Vizcaíno F,Zaza A,Valenzuela C,González T

更新日期：2010-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition is implicated in the remodelling of tissues during development and in the adult life. In the heart, it gives origin to progenitors of fibroblasts, coronary endothelium, smooth muscle cells, and cardiomyocytes. Moreover, epicardially-derived cells determine myocardial wall thickness an...

journal_title：Journal of molecular and cellular cardiology

authors： Di Meglio F,Castaldo C,Nurzynska D,Romano V,Miraglia R,Bancone C,Langella G,Vosa C,Montagnani S

更新日期：2010-11-01 00:00:00

abstract：:While much is known about the deleterious effects of pro-inflammatory cytokines on development of vascular disease, little is reported on the direct effects of anti-inflammatory cytokines on the vascular smooth muscle cell (VSMC) response to injury. Interleukin-19 (IL-19) is a recently described Th2, anti-inflammatory...

journal_title：Journal of molecular and cellular cardiology

authors： Cuneo AA,Herrick D,Autieri MV

更新日期：2010-10-01 00:00:00

abstract：:The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a highly reproducible mod...

journal_title：Journal of molecular and cellular cardiology

authors： Kreymborg Kg,Uchida S,Gellert P,Schneider A,Boettger T,Voswinckel R,Wietelmann A,Szibor M,Weissmann N,Ghofrani AH,Schermuly R,Schranz D,Seeger W,Braun T

更新日期：2010-10-01 00:00:00

abstract：:The ubiquitin-proteasome system plays an important role in regulating muscle mass. Inducible immunoproteasome subunits LMP-2 and LMP-7 are constitutively expressed in the heart; however, their regulation and functions are poorly understood. We here investigated the hypothesis that immunoproteasomes regulate cardiac mu...

journal_title：Journal of molecular and cellular cardiology

authors： Zu L,Bedja D,Fox-Talbot K,Gabrielson KL,Van Kaer L,Becker LC,Cai ZP

更新日期：2010-07-01 00:00:00

abstract：:Screening for cell surface proteins up-regulated under stress conditions may lead to the identification of new therapeutic targets. To search for genes whose expression was enhanced by treatment with oligomycin, a mitochondrial-F(0)F(1) ATP synthase inhibitor, signal sequence trapping was performed in H9C2 rat cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Nagao K,Ono K,Iwanaga Y,Tamaki Y,Kojima Y,Horie T,Nishi H,Kinoshita M,Kuwabara Y,Hasegawa K,Kita T,Kimura T

更新日期：2010-06-01 00:00:00

abstract：:Spectrin is a large, flexible protein that stabilizes membranes and organizes proteins and lipids into microdomains in intracellular organelles and at the plasma membrane. Alternative splicing occurs in spectrins, but it is not yet clear if these small variations in structure alter spectrin's functions. Three alternat...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang Y,Resneck WG,Lee PC,Randall WR,Bloch RJ,Ursitti JA

更新日期：2010-06-01 00:00:00

abstract：:Chronic pressure overload to the heart leads to cardiac hypertrophy and failure through processes that involve reorganization of subcellular compartments and alteration of established signaling mechanisms. To identify proteins contributing to this process, we examined changes in nuclear-associated myofilament proteins...

journal_title：Journal of molecular and cellular cardiology

authors： Paulsson AK,Franklin S,Mitchell-Jordan SA,Ren S,Wang Y,Vondriska TM

更新日期：2010-06-01 00:00:00

abstract：:The myosin heavy chain (MHC) isoforms, alpha- and beta-MHC, are expressed in developmental- and chamber-specific patterns. Healthy human ventricle contains approximately 2-10% alpha-MHC and these levels are reduced even further in the failing ventricle. While down-regulation of alpha-MHC in failing myocardium is consi...

journal_title：Journal of molecular and cellular cardiology

authors： James J,Hor K,Moga MA,Martin LA,Robbins J

更新日期：2010-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes encoding sarcomere proteins. The mechanisms involved in the development of cardiac hypertrophy and heart failure remain poorly understood. Global proteomic profiling was used to study the cardiac proteome of mice predisposed to develo...

journal_title：Journal of molecular and cellular cardiology

authors： Lam L,Tsoutsman T,Arthur J,Semsarian C

更新日期：2010-05-01 00:00:00

abstract：:We have previously proposed that the heterogeneous collapse of mitochondrial inner membrane potential (DeltaPsi(m)) during ischemia and reperfusion contributes to arrhythmogenesis through the formation of metabolic sinks in the myocardium, wherein clusters of myocytes with uncoupled mitochondria and high K(ATP) curren...

journal_title：Journal of molecular and cellular cardiology

authors： Brown DA,Aon MA,Frasier CR,Sloan RC,Maloney AH,Anderson EJ,O'Rourke B

更新日期：2010-04-01 00:00:00

abstract：:Myocardial [ATP] falls in the failing heart. One potential compensatory mechanism for maintaining a near normal free energy of ATP hydrolysis (DeltaG approximately (ATP)), despite a fall in [ATP], may be the reduction of myocardial creatine (Cr). To test this, we conducted a longitudinal study using transgenic mice ov...

journal_title：Journal of molecular and cellular cardiology

authors： Shen W,Vatner DE,Vatner SF,Ingwall JS

更新日期：2010-04-01 00:00:00

abstract：:Vascular cells are very sensitive to their hemodynamic environment. Any change in blood pressure or blood flow can be sensed by endothelial and vascular smooth muscle cells and ultimately results in structural modifications within the vascular wall that accommodate the new conditions. In the case of hypertension, the ...

journal_title：Journal of molecular and cellular cardiology

authors： Lemarié CA,Tharaux PL,Lehoux S

更新日期：2010-03-01 00:00:00

abstract：:Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias, including congestive heart failure (CHF) and atrial fibrillation (AF). Inducibility of AF as a result of atrial fibrosis has been the subject of intense recent investigation since it is the most commonly encountered arrhythmi...

journal_title：Journal of molecular and cellular cardiology

authors： Pellman J,Lyon RC,Sheikh F

更新日期：2010-03-01 00:00:00

abstract：:The remodeling of a heart ventricle after myocardial infarction involves numerous inflammatory mediators that may trigger a long-lasting and a highly fibrogenic process. Likewise, in the kidney, acute and chronic injuries may lead to abnormal extracellular matrix deposition and eventually lead to the loss of renal fun...

journal_title：Journal of molecular and cellular cardiology

authors： Hertig A,Gangadhar T,Kalluri R

更新日期：2010-03-01 00:00:00

abstract：:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug flecainide inhibits RyR2 channels and prevents CPVT in mice and humans. Here we compared the effects of flecainide and tetracaine, a known RyR2 ...

journal_title：Journal of molecular and cellular cardiology

authors： Hilliard FA,Steele DS,Laver D,Yang Z,Le Marchand SJ,Chopra N,Piston DW,Huke S,Knollmann BC

更新日期：2010-02-01 00:00:00

abstract：:Lysophosphatidylcholine (LPC) accumulation in intracellular and/or interstitial space in cardiomyocytes may underlie as a mechanism for tachycardia and various arrhythmias during cardiac ischemia, which is usually accompanied by elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The present study was there...

journal_title：Journal of molecular and cellular cardiology

authors： Zheng M,Wang Y,Kang L,Shimaoka T,Marni F,Ono K

更新日期：2010-01-01 00:00:00

abstract：:Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source. CMPCs isolated from human fetal heart wer...

journal_title：Journal of molecular and cellular cardiology

authors： de Boer TP,van Veen TA,Jonsson MK,Kok BG,Metz CH,Sluijter JP,Doevendans PA,de Bakker JM,Goumans MJ,van der Heyden MA

更新日期：2010-01-01 00:00:00

abstract：:The insulin receptor substrate (IRS) family plays important roles in cellular growth, signaling, and survival in the brain. We identified IRS6/Dok-5, a member of the IRS family, also expressed in heart. Dok-5 expression level significantly increased during cardiomyocyte differentiation of P19CL6 cells. To understand t...

journal_title：Journal of molecular and cellular cardiology

authors： Wen J,Xia Q,Wang C,Liu W,Chen Y,Gao J,Gong Y,Yin B,Ke Y,Qiang B,Yuan J,Peng X

更新日期：2009-12-01 00:00:00

abstract：:Atrial fibrillation (AF) is commonly associated with chronic dilatation of the left atrium, both in human disease and animal models. The immediate signaling enzyme phospholipase C (PLC) is activated by mechanical stretch to generate the Ca2+-releasing messenger inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) and sn-1,2-di...

journal_title：Journal of molecular and cellular cardiology

authors： Woodcock EA,Grubb DR,Filtz TM,Marasco S,Luo J,McLeod-Dryden TJ,Kaye DM,Sadoshima J,Du XJ,Wong C,McMullen JR,Dart AM

更新日期：2009-11-01 00:00:00

abstract：:Extracellular superoxide dismutase (EC-SOD) is an antioxidant that protects the heart from ischemia and the lung from inflammation and fibrosis. The role of cardiac EC-SOD under normal conditions and injury remains unclear. Cardiac toxicity, a common side effect of doxorubicin, involves oxidative stress. We hypothesiz...

journal_title：Journal of molecular and cellular cardiology

authors： Kliment CR,Suliman HB,Tobolewski JM,Reynolds CM,Day BJ,Zhu X,McTiernan CF,McGaffin KR,Piantadosi CA,Oury TD

更新日期：2009-11-01 00:00:00

abstract：:The mechanisms underlying the Frank-Starling Law of the heart are elusive and the prevalent notion suggests that it is afterload independent. However, isolated fiber studies reveal that the afterload determines cardiac function through cross-bridge dependent mechanisms. The study explores the roles of the afterload, i...

journal_title：Journal of molecular and cellular cardiology

authors： Sela G,Landesberg A

更新日期：2009-10-01 00:00:00

abstract：:Calcium (Ca(2+)) signaling plays a major role in a wide range of physiological functions including control and regulation of cardiac and skeletal muscle performance and vascular tone. As all Ca(2+) signals require proteins to relay intracellular Ca(2+) oscillations downstream to different signaling networks, a specifi...

journal_title：Journal of molecular and cellular cardiology

authors： Kraus C,Rohde D,Weidenhammer C,Qiu G,Pleger ST,Voelkers M,Boerries M,Remppis A,Katus HA,Most P

更新日期：2009-10-01 00:00:00

abstract：:The transcription factor scleraxis has been implicated in regulating the development of collagen-rich tissues such as tendons and cardiac valves, but its role in general collagen synthesis in the heart is unknown. Scleraxis expression in cardiac fibroblasts was examined, and its ability to regulate gene expression of ...

journal_title：Journal of molecular and cellular cardiology

authors： Espira L,Lamoureux L,Jones SC,Gerard RD,Dixon IM,Czubryt MP

更新日期：2009-08-01 00:00:00